She was a Vice-President of Japanese Pulmonary Circulation and Pulmonary Hypertension Society (JPCPHS) during 2015-2021. She graduated from Nagasaki University School of Medicine and obtained her Ph.D. from Osaka University Graduate School of Medicine.
From 1987, she worked at The Center for Cardiovascular Research, The Toronto Hospital, and since 1990, conducted research on signal transduction of cytokines and growth factors in cardiac myocytes at the Department of Cardiology, Osaka University Graduate School of Medicine.
She was appointed as Vice-President of Osaka University in 2014, and also worked as a Trustee of National Cerebral and Cardiovascular Center (2018-2024) and an Auditor of National Institute for Quantum Science and Technology, Japan (2020-2024).
Although she has a longstanding interest in genetics and biological mechanisms of the development of cardiomyopathy, her research interests include pulmonary circulation and cardiopulmonary interrelations from the viewpoints of genetics and inflammation
Over 100 reviewed basic and clinical research papers;
Successful treatment of severe combined post- and pre-capillary pulmonary hypertension in a patient with idiopathic restrictive cardiomyopathy. Pulm Circ. 2018 Jul-Sep;8(3)
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2677-86. doi: 10.1073/pnas.1424774112.
The challenge of the "estrogen paradox" in pulmonary arterial hypertension. Circ J. 2013;77(8):1992-3.
Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection. Intern Med. 2011;50(2):119-24.
1979/07 MD. NATIONAL DEFENSE MEDICAL UNIVERSITY
1995/07-1997/07 -Post-doctoral fellowship, Hospital of the University of Pennsylvania, USA
2015/02 & /06 -Master class of Pulmonary Vascular Disease, Bologna University Hospital, Bologna, Italy
2018/12- Director, Center for PH and PVD, CMUH, Taichung, Taiwan
2015/04-2027/04 -Chairperson, Taiwan Pulmonary Hypertension Association (TPHA)
Pulmonary hypertension including clinical and genetic studies
Pulmonary hypertension publication in recent 5 years
Liang K-W, Chang S-K, Chen Y-W, Tsai W-J, Wang K-Y*(corresponding author). A cluster of heritable pulmonary arterial hypertension cases in a family with all three siblings carrying the same novel AQP1 c.273C>G variant-a case report. Pulm Circ. 2023;e12211. https: //doi.org/10.1002/pul2.12211
I Hsin Tai, Tsung-Cheng Shyu, Kai-Sheng Hsieh, Ke-Wei Chen, Wan-Jane Tsai, Kuo-Yang Wang*(corresponding author). Case report: The impact of percutaneous atrial septal defect closure in pulmonary hypertension with co-existing cor triatriatum sinister and multiple cardiac comorbidities. Front. Cardiovasc. Med., 07 September 2022 Sec. Cardiovascular Therapeutics https://doi.org/10.3389/fcvm.2022.913391
Kae-Woei Liang, Sheng-Kai Chang, Yu-Wei Chen, Wei-Wen Lin, Kuo-Yang Wang*(corresponding author). Whole exome sequencing of patients with primary pulmonary arterial hypertension in central Taiwan. Front Cardiovasc Med. 22 June 2022, doi: 10.3389/fcvm.2022.911649
Liang KW, Wei HJ, Wang KY*(corresponding author). Sustained hemodynamic and clinical improvements for a patient with idiopathic pulmonary arterial hypertension over 1.5 years after balloon atrial septostomy: a case report. Front Cardiovasc Med. 2022 Apr 7;9:868123. doi:10.3389/fcvm.2022.868123. eCollection 2022
College: Harvard University, 1989, A.B. (Magna Cum Laude, Biology)
Medical School: University of Chicago Pritzker School of Medicine, 1994, M.D.
Internship: University of Chicago, Internal Medicine, 1994-1995, 1996-1998
Residency: University of California San Francisco, Anesthesiology, 1995-1996
Fellowship: University of California San Diego, Pulmonary and Critical Care Medicine, 1998-2001
Faculty at UCSD since 2001. Fellowship program director 2009-2017. Currently, Professor of Medicine in the Division of Pulmonary, Critical Care, Sleep Medicine, & Physiology. Section Chief of Pulmonary Vascular Medicine. Medical Director of Pulmonary Thromboendarterectomy Program.
Evaluation and treatment of pulmonary arterial hypertension
Interventional and medical management of chronic thromboembolic disease
Perioperative management following pulmonary thromboendarterectomy
Balloon pulmonary angioplasty for chronic thromboembolic disease
Clinical trials in pulmonary hypertension
As of Nov 2025: 132 peer-reviewed publications on pulmonary hypertension including, pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Lead author for the 5th, 6th, and 7th World Symposium on Pulmonary Hypertension task force on “Chronic Thromboembolic Pulmonary Hypertension”. 4th World Symposium on Pulmonary Hypertension task force member: “Endpoints and Clinical Trial Design in PAH” and “Interventional and Surgical Modalities of Treatment in PH”.
1976 – 1978 Premedical Course, Tokyo Medical and Dental University, Chiba, Japan
1978 – 1982 M.D., Tokyo Medical and Dental University, Tokyo, Japan
2000 Ph.D. (Doctor of Medicine), Tokyo Medical and Dental University, Tokyo, Japan
1991 Board certified in Pediatrics, Japanese Pediatric Society
2011 Board certified in Pediatric Cardiologist, Japanese Society of Pediatric Cardiology and Cardiac Surgery
2011 Board certified in PALS provider, American Heart Association
Japanese Medical Specialty Board and Instructor of Pediatrics
Specialty Board of Pediatric Cardiology
Honorary fellow of Japanese Society of Pediatric Cardiology and Cardiac Surgery
Honorary fellow of Japanese Pulmonary Circulation and Pulmonary Hypertension Society
Implantable Cardioverter Defibrillator for Primary Prevention in Children With Arrhythmogenic Right Ventricular Cardiomyopathy: A Case Series. Cureus. 2025 Jan 10;17(1):e77253
Systematic Review of the Application of Pulmonary Hypertension Treatments in Ventricular Septal Defect, Pulmonary Atresia, and Major Aortopulmonary Collateral Arteries. J Clin Med. 2026 Jan 30;15(3):1087. doi: 10.3390/jcm15031087